Preliminary human study examined d-limonene alongside THC
Small double-blind placebo-controlled human laboratory study
Published Mar 13, 2024 · Verified Oct 10, 2026
Study overview
In a controlled vaporization study, the highest combined d-limonene and THC condition reduced some self-reported anxiety and paranoia ratings compared with THC alone. Other measured THC effects were unchanged.
Evidence & interpretation
Human experimental evidence for a specific terpene interaction, requiring replication and broader testing. Findings do not support strain recommendations, therapeutic claims or instructions to combine substances.
Limitations
Preliminary evidence: 20 adults completed the main sessions, and only 12 completed the highest combination condition. Isolated substances and acute exposure do not establish how retail cannabis products behave or prove a general entourage effect. A related patent application is disclosed.
Original citation
Drug and Alcohol Dependence / PubMed ↗
This research entry is informational and is not a clinical recommendation. Consult qualified health professionals about personal medical questions.