Research, without the hype.
Peer-reviewed human research and Canadian policy studies, with study design, original citations and limitations. Preliminary results remain preliminary; associations do not establish causation.
Alberta hospitalization study found no increase attributable to legalization
Researchers examined Alberta adults across periods before legalization, after flower legalization and after legalization of edibles, extracts and topicals. They did not identify increased hospitalization risk associated with legalization in either younger or older adult groups.
Cohort study with interrupted time series analysis
May 19, 2024 · Journal of Addictive Diseases / PubMed
Small CBD trial found no significant reduction in trauma-script reactivity
A trial in 42 trauma-exposed participants with elevated stress found no statistically significant reduction in anxiety, distress or heart-rate response to personalized trauma scripts, either after initial CBD administration or one week of repeated administration.
Randomized double-blind placebo-controlled trial
Jul 3, 2024 · Journal of Traumatic Stress / PubMed
Preliminary human study examined d-limonene alongside THC
In a controlled vaporization study, the highest combined d-limonene and THC condition reduced some self-reported anxiety and paranoia ratings compared with THC alone. Other measured THC effects were unchanged.
Small double-blind placebo-controlled human laboratory study
Mar 13, 2024 · Drug and Alcohol Dependence / PubMed
Minimum purchase age and Canadian cannabis hospitalizations
Researchers compared cannabis-related hospitalizations above and below provincial minimum purchase ages from 2015 to 2022. After legalization, rates declined among people below the legal age while continuing to increase among those above it.
Population-based controlled interrupted time series
May 22, 2025 · American Journal of Public Health / PubMed
Oral CBD did not consistently reduce THC effects in a controlled trial
In 37 healthy volunteers, the highest tested oral CBD condition increased several effects of oral THC and THC exposure in blood. Lower CBD conditions did not significantly change the measured THC effects.
Randomized double-blind placebo-controlled crossover trial
Jul 25, 2024 · Clinical Pharmacology & Therapeutics / PubMed
This is an initial curated library, not a comprehensive systematic review. Research summaries do not provide medical advice.